Any entity subject to the US Constitution must play by its rules. That includes the US Federal Government and the serf states. But in 2012, Washington completely ignores the Constitution and does exactly what it desires. There are absolutely no control mechanisms on the Federal Government. Ockham’s Razor will indicate that any effort to reform the United States cannot succeed, since remaining a part of the system requires slavish obedience to it. Voting in Federal elections only mollifies the voter and makes him believe his vote matters. Nullification cannot be successful since the States cannot enforce it.
The point of secession is to avoid a Civil War. But we remember how that turned out the first time it was attempted. Doesn't mean we shouldn't try it again, this time with lessons learned.